Chloroplast Engineering in Biopharmaceuticals

The unique advantages of chloroplast transformation make it very promising. With the rapid development of chloroplast genetic engineering technology, chloroplast engineering can be applied in various fields to benefit human beings and nature. Based on our extensive experience in the field of chloroplast engineering, researchers have successfully applied chloroplast genetic engineering from theory to biopharmaceuticals including vaccine antigens.

Here, Lifeasible is committed to providing global customers with the best solutions for chloroplast engineering in biopharmaceuticals. Our customized solutions will guarantee your 100% satisfaction.

Introduction

Plant systems have long been used in the production and development of biopharmaceuticals, including vaccines, enzymes, plasma proteins, antibodies, etc. Researchers have been using plant nuclear genomes to express human therapeutic proteins. But the long duration of nuclear transformation and the low and variable expression levels limit their application. In addition, the high price of current protein drugs makes it unaffordable for many people. Chloroplasts are widely used for the production of therapeutic proteins and vaccines as ideal hosts for transgene expression. Scientists have successfully used transgenic chloroplasts to produce a variety of functional therapeutic proteins, including HSA, IFN, insulin, growth hormone, etc. In addition, the chloroplast expression system has been successfully used to produce a variety of vaccines, including cholera, anthrax, tetanus, plague, canine parvovirus, HCV, rotavirus, amoeba, malaria, etc.

Fig. 1. Overview of production system of plant-based biopharmaceuticals and plant biomass. (Moon K B, et al., 2019)

Our Solutions

Chloroplast transformation technology is currently producing functional human and animal therapeutic proteins in an environmentally friendly manner. Lifeasible is focused on developing a variety of state-of-the-art methods and technologies to bring chloroplast genetic engineering from theoretical research to biopharmaceutical practice. Our team has a strong interest in the application of chloroplast engineering and hopes to bring more valuable and innovative solutions to people through the chloroplast gene transformation platform.

Our engineers use tobacco as a model system to produce therapeutic proteins and other transgenic vaccines through plant expression systems. With years of experience in chloroplast engineering, Lifeasible is committed to developing the application of chloroplast engineering in biopharmaceuticals to develop the safe, effective and economical therapeutic protein drugs and infectious disease vaccines for global customers. Our chloroplast engineering solutions in biopharmaceuticals are well established and you can choose with confidence. Here, our chloroplast engineering solutions in biopharmaceuticals include:

• Production of Chloroplast-Derived Vaccine Antigens
• Production of Chloroplast-Derived Therapeutic Proteins

Advantages of Chloroplast Engineering in Biopharmaceuticals

• Does not require expensive fermentation systems and is produced in a hydroponics greenhouse.
• Reduce the cost of its production, purification, processing, refrigeration, transportation and delivery.
• With thermal stability.
• Protein production is safe and free of human pathogens.
• Suitable for the production of therapeutic proteins as small as 20 amino acids and as large as 135 kDa.
• Store indefinitely at room temperature without losing its efficacy.
• Plant cell walls protect protein drugs from stomach acids and enzymes.
• Systemic and mucosal immunity developed.

Lifeasible has successfully used chloroplast transformation technology for abiotic and biotic stress tolerant plants, vaccines, biomaterials, biopharmaceuticals, phytoremediation and more. Here, we provide reliable, economical solutions for chloroplast engineering in biopharmaceuticals. Each project will be customized according to customer requirements and provide 24h after-sales service. Our clients have direct access to our experts and provide instant feedback on any online query. If you are interested in our services, please feel free to contact us.

References

1. Daniell H. (2006) Production of biopharmaceuticals and vaccines in plants via the chloroplast genome[J]. Biotechnology Journal: Healthcare Nutrition Technology. 1(10): 1071-1079.
2. Moon K B, Park J S, Park Y I, et al. (2019) Development of systems for the production of plant-derived biopharmaceuticals[J]. Plants. 9(1): 30.